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Endocrine Abstracts

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ea0086oc5.1 | Metabolism, Obesity and Diabetes | SFEBES2022

Human brown adipose tissue demonstrates substantial choline uptake for incorporation into phosphatidylcholines

Suchacki Karla , Ramage Lynne , Gray Calum , Rodrguez Blanco Giovanny , Choong Kwok T'ng , Boyle Luke , MacNaught Gillian , Gregoriades Maria-lena , Wakelin Sonia , von Kriegsheim Alex , Finch Andrew , Patel Dilip , van Beek Edwin , Stimson Roland

Background: 18F-fluorodeoxyglucose (18FDG) PET is commonly used to quantify brown adipose tissue (BAT) mass/activity in humans but requires cold exposure. Rodent brown (BAds) but not white adipocytes (WAds) exhibit high choline content, thus we hypothesised that human BAT would demonstrate substantial 18F-fluorocholine (18FCH) uptake in vivo during warm and cold conditions.Methods: (1)...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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